Typical attendees are the first and second year PhD students from biomedical programmes, but other participants are also very welcome. The main aim of the course is to provide information about the recent progress in the fields of molecular biology, genetics and biomedicine together with selected new biotechnology approaches (http://pdsb.avcr.cz).


The course takes place from November 2nd to November 13th, 2020. It will be held in the Milan Hašek Lecture Hall of the Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), Vídeňská 1083, Praha 4 Krč (Krč-campus of the biological institutes of the Czech Academy of Sciences).

In case of COVID-19 restrictions preventing the course on site, lectures will be streamed via Zoom.


All lectures will be held in English by active scientists.
The course is composed of ~ 40 lectures organized into the following thematic blocks:

Genomics: human genome-structure and evolution, nuclear microstructure and function, telomeres & rDNA & chromosome stability, telomeres and aging, meiotic recombination & hybrid sterility, organization and function of the 3D genome, mouse genome engineering by CRISPR technology;
Epigenetics: epigenetics of haematological malignances;
RNA: molecular biology of RNA polymerases, alternative splicing regulation, covalent RNA modifications, small RNA pathways;
Proteins: eukaryotic protein synthesis, protein structure determination by X-ray crystallography, proteomics and proteomes, prions, prion strains and prion diseases, intramembrane proteolysis & protein quality control;
Cell biology and signaling: microtubules and signal transduction, membrane microdomains, cellular iron-cause of oxidative stress, DNA damage and ferroptosis, DNA damage response and cellular checkpoints, eukaryotic flagella and cilia, transcriptional regulation during blood formation, function of ameloblastin in enamel formation and beyond, mitochondrial ATP synthases, cell-to-cell communication;
Development: insect genetic models for hormonal regulation of development;
Biomedicine: current concepts in tumor immunology, adaptive immunity – T cell total recall, genetics of unsolved rare diseases, genetics of autism and intellectual disability, molecular and genetic bases of bacterial virulence, epigenetics of hematological malignances , mitochondria – perspective target of antitumor therapy;
Virology: Antiviral prospects of gene editing technology, antiviral medicinal chemistry, Picorna-like virus biology, HIV biology and therapy.
Workshops: English in academic writing. Career paths in science-research and alternatives. Decision points: postdoc selection and postdoc interview. Research ethics and misconduct.
Discussion panel: PhD talks by selected PhD students.
At the end of the course participants receive the credit and the presentations will be available for download from a password-protected course website.


Accommodation can be arranged individually in colleges of the Charles University. Course attendees should as soon as possible send an e-mail to the Central reservation office: reservace@kam.cuni.cz and mention that you participate in the course.

Catering during the course includes coffee breaks. Lunch meals can be purchased in canteens in the Krč campus.


Bus line 138 takes you from the Kačerov underground line C station directly to the front gate (“Ústavy Akademie věd” stop) of the campus. Bus line 193 takes you from the Budějovická underground line C station to the stop “Zelené domky” from where you have to walk back for about 200 meters to the front gate of the campus.


Download the Invitation (PDF)

Registration is closed.