Typical attendees are the first and second year PhD students from biomedical programmes, but other participants are also very welcome. The main aim of the two-week lecture course is to inform the participants about the recent progress in fields of molecular biology, genetics and biomedicine together with selected new biotechnology approaches ( The course is accredited (MPGS0034) at the Charles University.


The course takes place from October 31st to November 11th, 2022. It will be held in the Milan Hašek Lecture Hall of the Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), Vídeňská 1083, Praha 4 Krč (Krč-campus of the biological institutes of the Czech Academy of Sciences).

In case of COVID-19 restrictions preventing the course on site, lectures will be streamed via Zoom.


All lectures will be given in English by active scientists.
The course consists of ~ 40 lectures organized into the following thematic blocks:

DNA/cell nucleus: nuclear microstructure-function relationship, organization and function of the 3D genome, human genome structure and evolution.
RNA: pivotal role of RNA polymerase in gene expression, organization and regulation of RNA polymerase II transcription, non-canonical RNA caps, piRNA pathways, regulation of RNA splicing.
Proteins: eukaryotic protein synthesis, ribosome structure and function, structural biology tools, proteomics and proteomes.
Cell biology and signaling: microtubules and signal transduction, membrane microdomains, cellular iron-oxidative stress-DNA damage-ferroptosis, eukaryotic flagella and cilia, genome integrity in healthy cells and cancer, endothelial cells: metabolism and heterogeneity in disease, multifaceted mitochondrial ATP synthases, insect hormonal signaling exploration via molecular genetics and chemical biology, memory of immune system.
Genomics: meiotic recombination and hybrid sterility, strategies for manipulating gene expression, high throughput gene expression analysis, gene editing in antiviral research.
Biomedicine: current concepts in tumor immunology and immunotherapy, prion, prion strains and prion diseases, rare genetic variants in Mendelian complex diseases, genetics of intellectual disability and autism, leukemogenesis: genetics vs epigenetics, comparative biology of aging, ameloblastin in enamel formation and beyond, molecular tricks of human bacterial pathogens, germline genetic changes causing human tumors, DNA strand breaks and neurodegenerative disease, transcriptional regulation during blood formation, biological clock.
Developmental biology: converting cellular-scale chirality to organismal left-right symmetry breaking, development of the head and neck, Notch signaling.
Workshops: Writing in scientific English, research ethics and scientific misconduct, career paths in science-research and alternatives, scientific communication. Life with science.
At the end of the course participants receive the credit and the presentations will be available for download from a password-protected website.


Accommodation can be arranged individually in colleges of the Charles University. Course attendees should as soon as possible contact by e-mail the Central reservation office ( and mention that they participate in the course.

During the course will be available coffee breaks with snacks. Lunches can participants purchase during lunch breaks in one of the two canteens in the Krč campus.


Bus line 138 takes you from the Kačerov underground line C station directly to the front gate (“Ústavy Akademie věd” stop) of the campus. Bus line 193 takes you from the Budějovická underground line C station to the stop “Zelené domky” from where you have to walk back for about 200 meters to the front gate of the campus.


Download the Invitation (PDF)

Registration is closed.