47th LECTURE COURSE (2023)
MODULE:
DNA/nucleus
Monday 30. 10. 2023
08:40 – 09:00
opening remarks & organizational items, J. Jonák/P. Svoboda
09:00 – 09:50
The cell nucleus: relationship between microstructure and function, P. Hozák
09:50 – 10:40
Human genome structure and evolution, J. Pačes
11:00 – 11:50
Evolution of genes and gene expression programs, P. Svoboda
13:00 – 13:50
Organization and function of the 3D genome, J. Doležel
14:10 – 15:00
Telomeres and telomerases: structure, functions and evolution, J. Fajkus
MODULE:
RNA Biology
Tuesday 31. 10. 2023
09:00 – 09:50
Alternative splicing, D. Staněk
09:50 – 10:40
Cyclin-dependent kinases in transcription and splicing, D. Blažek
11:00 – 11:50
tRNA metabolism, Z. Paris
13:00 – 13:50
dsRNA response in innate immunity/ADARs, M. O’Connell
14:10 – 15:00
Genome defense by small RNAs in mammals, P. Svoboda
MODULE:
Proteins
Wednesday 1. 11. 2023
09:00 – 09:50
Eukaryotic protein synthesis, L. Valášek
09:50 – 10:40
Proteomics – expectation, promises and reality, J. Petrák
11:00 – 11:50
Protein structure determination by X-ray crystallography, P. Řezáčová
13:00 – 13:50
Protein turnover in cancer and development: insights into cellular dynamics, L. Čermák
14:10 – 15:00
Protein structure predictions, J. Vondrášek
MODULE:
Cell Biology, Cytoskeleton & Co.
Thursday 2. 11. 2023
09:00 – 09:50
Ensemble dynamics of cytoskeletal proteins, Z. Lánský
09:50 – 10:40
Microtubules and signal transduction, Pa. Dráber
11:00 – 11:50
Biology of eukaryotic flagella and cilia, V. Varga
13:00 – 13:50
Cytoskeletal organization in cell and tissue mechanics, M Gregor
14:10 – 15:00
Nuclear mechanobiology and aging, S. Osmanagic-Myers
MODULE:
Cell Biology
Friday 3. 11. 2023
09:00 – 09:50
Cellular iron as a source of oxidative stress, DNA damage and ferroptosis, J. Pláteník
09:50 – 10:40
Mitochondria, V. Hampl
11:00 – 11:50
Cell biology of lipids – current challenges & approaches, A. Nadler
MODULE:
Development
Monday 6. 11. 2023
09:00 – 09:50
Oocyte-to-embryo transition, H. Fulková
09:50 – 10:40
Therapeutic models in regenerative medicine and oncology, L. Láníková
11:00 – 11:50
Zebrafish as a model system in developmental biology, P. Fabian
13:00 – 13:50
Comparative developmental biology, A. Hejnol
14:10 – 15:00
Hematopoiesis, O. Svoboda
MODULE:
Biomedicine, Genetics & Genomics
Tuesday 7. 11. 2023
09:00 – 09:50
Tumor immunology and cancer immunotherapy, R. Spíšek
09:50 – 10:40
Reading biological information, M. Kolář
11:00 – 11:50
Epigenetic disorders: from understanding to potential therapy, J. Procházka
13:00 – 13:50
Guided nucleases – an introduction, R. Sedláček
14:10 – 15:00
CRISPR/Cas in biomedicine, R.O. Bak
MODULE:
Biomedicine, Cancer
Wednesday 8. 11. 2023
09:00 – 09:50
Chromosomal aberrations in cancer cells – the penalties and the rewards, Z. Storchová
09:50 – 10:40
ADP-ribose metabolism, DNA strand breaks and human disease, H. Hanzlíková
11:00 – 11:50
Regulation of DNA replication in healthy and cancer cells, H. Polášek-Sedláčková
13:00 – 13:50
Metabolic communication in tumors: focus on nucleotide metabolism, K. Rohlenová
14:10 – 15:00
DNA damage response and cellular checkpoints in cancer, L. Macůrek
MODULE:
Biomedicine, Immuno
Thursday 9. 11. 2023
09:00 – 09:50
Epigenetic regulation in leukemia predisposition and myelodysplastic syndromes, T. Stopka
09:50 – 10:40
Metabolic vulnerabilities in leukemia, J. Starková
11:00 – 11:50
Gene editing strategies for correcting inherited bone marrow failure syndromes, K. Škvárová
13:00 – 13:50
Targeting proinflammatory cytokines in autoimmune diseases, Pe. Dráber jun.
14:10 – 15:00
Rare genetic variants in Mendelian complex diseases, S. Kmoch
MODULE:
Career Development, Discussion Panel
Thursday 9. 11. 2023
15:20 – 16:30
Career paths – research and alternatives, D. Staněk
16:30 – 18:00
Career reflections and decisions: open discussion with people with different career paths
18:00 – 22:00
dinner & socializing
MODULE:
Career Development
Friday 10. 11. 2023
09:00 – 10:10
Decision points: postdoc selection and postdoc interview, P. Svoboda
10:40 – 12:00
Scientific misconduct, P. Svoboda
12:00
Credits