Rubrika: Uncategorized

Programme / Lectures – 2024

MODULE:

DNA/nucleus

Monday 4. 11. 2024
J. Jonák/P. Svoboda
08:40 – 09:00
opening remarks & organizational items
opening remarks & organizational items, J. Jonák/P. Svoboda
P. Hozák
09:00 – 09:50
The cell nucleus: relationship between microstructure and function
The cell nucleus: relationship between microstructure and function, P. Hozák
B. van Steensel
09:50 – 10:40
Genome – nuclear lamina interactions
Genome – nuclear lamina interactions, B. van Steensel
J. Pačes
11:00 – 11:50
Human genome
Human genome, J. Pačes
R. Reifová
13:00 – 13:50
The germline-restricted chromosome of songbirds
The germline-restricted chromosome of songbirds, R. Reifová
H. Šimková
14:10 – 15:00
3D organisation of a plant genome: dynamics and function
3D organisation of a plant genome: dynamics and function, H. Šimková
MODULE:

RNA Biology

Tuesday 5. 11. 2024
L. Krásný
09:00 – 09:50
RNA polymerase and bacterial transcription
RNA polymerase and bacterial transcription, L. Krásný
H. Cahová
09:50 – 10:40
Non-canonical RNA caps – from their discovery to their role
Non-canonical RNA caps – from their discovery to their role, H. Cahová
D. Staněk
11:00 – 11:50
Regulation of RNA splicing
Regulation of RNA splicing, D. Staněk
J. Hnilicová
13:00 – 13:50
Non-coding RNAs
Non-coding RNAs, J. Hnilicová
P. Svoboda
14:10 – 15:00
Mammalian RNA interference: facts and myths
Mammalian RNA interference: facts and myths, P. Svoboda
MODULE:

Proteins

Wednesday 6. 11. 2024
L. Valášek
09:00 – 09:50
Eukaryotic protein synthesis
Eukaryotic protein synthesis, L. Valášek
J. Petrák
09:50 – 10:40
Unveiling the Proteomes: Capabilities and Challenges of Current Proteomics
Unveiling the Proteomes: Capabilities and Challenges of Current Proteomics, J. Petrák
V. Veverka
11:00 – 11:50
Structural Biology Tools
Structural Biology Tools, V. Veverka
K. Holada
13:00 – 13:50
Prions, prion strains and expanding universe of prion diseases
Prions, prion strains and expanding universe of prion diseases, K. Holada
G. Demo
14:10 – 15:00
Ribosome structure and function
Ribosome structure and function, G. Demo
MODULE:

Cell Biology, Cytoskeleton & Co.

Thursday 7. 11. 2024
Pa. Dráber
09:00 – 09:50
Microtubules and signal transduction
Microtubules and signal transduction, Pa. Dráber
M. Balaštík
09:50 – 10:40
Mictotuble dynamics in neuoronal developpment
Mictotuble dynamics in neuoronal developpment, M. Balaštík
K. Schwarzerová
11:00 – 11:50
Cytoskeletal control of plant orgnaelle homeostasis
Cytoskeletal control of plant orgnaelle homeostasis, K. Schwarzerová
A. Dammermann
13:00 – 13:50
Centrosome and cilium biogenesis – insights from worms and flies
Centrosome and cilium biogenesis – insights from worms and flies, A. Dammermann
M. Gregor
14:10 – 15:00
Integrative biology
Integrative biology , M. Gregor
MODULE:

Cell Biology

Friday 8. 11. 2024
V. Varga
09:00 – 09:50
Biology of eukaryotic flagella and cilia
Biology of eukaryotic flagella and cilia, V. Varga
P. Doležal
09:50 – 10:40
Mitochondrial evolution: back to basics
Mitochondrial evolution: back to basics, P. Doležal
S. Martens
11:00 – 11:50
Mechanisms of Selective Autophagy
Mechanisms of Selective Autophagy, S. Martens
MODULE:

Development

Monday 11. 11. 2024
H. Vu
09:00 – 09:50
Planarian Growth and Regeneration
Planarian Growth and Regeneration, H. Vu
L. Láníková
09:50 – 10:40
In vitro Models in Development, Regenerative Medicine and Oncology
In vitro Models in Development, Regenerative Medicine and Oncology, L. Láníková
P. Fabian
11:00 – 11:50
Zebrafish as a model system in developmental biology
Zebrafish as a model system in developmental biology, P. Fabian
M. Kaucká
13:00 – 13:50
The development and evolution of facial shape
The development and evolution of facial shape, M. Kaucká
H. Fulková
14:10 – 15:00
Oocyte-to-embryo transition
Oocyte-to-embryo transition, H. Fulková
MODULE:

Biomedicine, Genetics & Genomics

Tuesday 12. 11. 2024
S. Kmoch
09:00 – 09:50
Rare genetic variants in Mendelian complex diseases
Rare genetic variants in Mendelian complex diseases, S. Kmoch
J. Procházka
09:50 – 10:40
Epigenetic disorders: from understanding to potential therapy
Epigenetic disorders: from understanding to potential therapy, J. Procházka
J. Hejnar
11:00 – 11:50
Antiviral prospects of gene editing technology
Antiviral prospects of gene editing technology, J. Hejnar
J. Gruenewald
13:00 – 13:50
Base and prime editors
Base and prime editors, J. Gruenewald
M. Kolář
14:10 – 15:00
Reading biological information
Reading biological information, M. Kolář
MODULE:

Biomedicine, Cancer

Wednesday 13. 11. 2024
H. Hanzlíková
09:00 – 09:50
Metabolism of ADP-ribose as target for cancer therapy
Metabolism of ADP-ribose as target for cancer therapy, H. Hanzlíková
Z. Kleibl
09:50 – 10:40
Germline genetic changes causing human tumors
Germline genetic changes causing human tumors, Z. Kleibl
Z. Sumbalová Koledová
11:00 – 11:50
Fibroblasts: The force behind mammary gland development and breast cancer
Fibroblasts: The force behind mammary gland development and breast cancer, Z. Sumbalová Koledová
J. Neužil
13:00 – 13:50
Mitochondria on the move: From horizonal mitochondrial transfer to liver regeneration
Mitochondria on the move: From horizonal mitochondrial transfer to liver regeneration, J. Neužil
V. Hlaváčková Pospíchalová
14:10 – 15:00
Ovarian cancer and Extracellular Vesicles
Ovarian cancer and Extracellular Vesicles, V. Hlaváčková Pospíchalová
MODULE:

Biomedicine, Immuno

Thursday 14. 11. 2024
M. Alberich Jordà
09:00 – 09:50
Regulating the production of immune cells
Regulating the production of immune cells, M. Alberich Jordà
O. Štěpánek
09:50 – 10:40
Immune memory
Immune memory, O. Štěpánek
P. Šebo
11:00 – 11:50
Molecular tricks of bacterial pathogens to manipulate the host
Molecular tricks of bacterial pathogens to manipulate the host, P. Šebo
D. Filipp
13:00 – 13:50
Central and peripheral immune tolerance
Central and peripheral immune tolerance, D. Filipp
J. Abramson
14:10 – 15:00
Immune tolerance & Autoimmunity
Immune tolerance & Autoimmunity, J. Abramson
MODULE:

Career Development, Discussion Panel

Thursday 14. 11. 2024
D. Staněk
15:20 – 16:30
Career paths – research and alternatives
Career paths – research and alternatives, D. Staněk
16:30 – 18:00
Career reflections and decisions: open discussion with people with different career paths
Career reflections and decisions: open discussion with people with different career paths
18:00 – 22:00
dinner & socializing
dinner & socializing
MODULE:

Career Development

Friday 15. 11. 2024
P. Svoboda
09:00 – 10:10
Scientific misconduct
Scientific misconduct, P. Svoboda
P. Svoboda
10:40 – 12:00
Conflict management
Conflict management, P. Svoboda
12:00
Credits
Credits

Programme / Lectures – 2021

MODULE:

DNA/nucleus

Monday 1. 11. 2021
08:30 – 09:30
registration, refreshment
registration, refreshment
J. Jonák/P. Svoboda
09:30 – 09:50
opening remarks
opening remarks, J. Jonák/P. Svoboda
P. Hozák
09:50 – 10:40
The cell nucleus: relationship between microstructure and function
The cell nucleus: relationship between microstructure and function, P. Hozák
J. Fajkus
11:00 – 11:50
Plant telomeres
Plant telomeres, J. Fajkus
J. Hejnar
13:00 – 13:50
Retroviruses. Arm Race between Virus and Cell
Retroviruses. Arm Race between Virus and Cell, J. Hejnar
D. Odom
14:10 – 15:00
Lesion segregation as a novel mechanism shaping cancer genome evolution
Lesion segregation as a novel mechanism shaping cancer genome evolution, D. Odom
MODULE:

RNA Biology

Tuesday 2. 11. 2021
M. Frey
09:00 – 09:50
RNA 5‐methylcytosine drives metabolic reprogramming required for metastasis
RNA 5‐methylcytosine drives metabolic reprogramming required for metastasis, M. Frey
D. Staněk
09:50 – 10:40
Alternative splicing regulation
Alternative splicing regulation, D. Staněk
L. Krásný
11:00 – 11:50
The RNAP Vehicle: Starting and Stopping
The RNAP Vehicle: Starting and Stopping, L. Krásný
P. Svoboda
13:00 – 13:50
Small RNAs in mammalian germ cells
Small RNAs in mammalian germ cells, P. Svoboda
Š. Vanáčová
14:10 – 15:00
Do I talk to Me?
Do I talk to Me?, Š. Vanáčová
MODULE:

Proteins

Wednesday 3. 11. 2021
J. Petrák
09:00 – 09:50
Proteomics – expectations and the reality
Proteomics – expectations and the reality, J. Petrák
P. Řezáčová
09:50 – 10:40
Protein structure determination by X‐ray crystallography
Protein structure determination by X‐ray crystallography, P. Řezáčová
K. Kubíček
11:00 – 11:50
Cryo EM: From organelles to atomic-resolution structures of molecules inside the cell
Cryo EM: From organelles to atomic-resolution structures of molecules inside the cell, K. Kubíček
L. Čermák
13:00 – 13:50
Protein‐degradation ‐ ubiquitin ligases
Protein‐degradation ‐ ubiquitin ligases, L. Čermák
J. Vondrášek
14:10 – 15:00
Protein structure predictions
Protein structure predictions, J. Vondrášek
MODULE:

Cell Biology

Thursday 4. 11. 2021
L. Valášek
09:00 – 09:50
Eukaryotic protein synthesis
Eukaryotic protein synthesis, L. Valášek
V. Varga
09:50 – 10:40
Biology of eukaryotic flagella and cilia
Biology of eukaryotic flagella and cilia, V. Varga
Pa. Dráber
11:00 – 11:50
Microtubules and signal transduction
Microtubules and signal transduction, Pa. Dráber
A. Sumová
13:00 – 13:50
Biological clock
Biological clock, A. Sumová
J. Pláteník
14:10 – 15:00
Cellular iron as a source of oxygen radicals and DNA damage
Cellular iron as a source of oxygen radicals and DNA damage, J. Pláteník
MODULE:

Signaling

Friday 5. 11. 2021
H. Hanzlíková
09:00 – 09:50
Sensing and repairing DNA strand breaks
Sensing and repairing DNA strand breaks, H. Hanzlíková
V. Bryja
09:50 – 10:40
Wnt signaling
Wnt signaling, V. Bryja
V. Hořejsí
11:00 – 11:50
Membrane microdomains and their biological roles ‐ facts and artifacts
Membrane microdomains and their biological roles ‐ facts and artifacts, V. Hořejsí
MODULE:

Development

Monday 8. 11. 2021
P. Hájková
09:00 – 09:50
germline reprogramming
germline reprogramming, P. Hájková
H. Fulková
09:50 – 10:40
oocyte‐to‐embryo transition
oocyte‐to‐embryo transition, H. Fulková
P. Bartůněk
11:00 – 11:50
hematopoiesis
hematopoiesis, P. Bartůněk
M. Jindra
13:00 – 13:50
Insect development
Insect development, M. Jindra
J. Mašek
14:10 – 15:00
Notch signaling in development
Notch signaling in development, J. Mašek
MODULE:

Genetics & Genomics

Tuesday 9. 11. 2021
J. Pačes
09:00 – 09:50
Strucutre and evolution of the SARS‐CoV‐2 genome
Strucutre and evolution of the SARS‐CoV‐2 genome, J. Pačes
S. Kmoch
09:50 – 10:40
Rare genetic variants in Mendelian complex diseases
Rare genetic variants in Mendelian complex diseases, S. Kmoch
Z. Sedláček
11:00 – 11:50
Genetics of intellectual disability and autism
Genetics of intellectual disability and autism, Z. Sedláček
R. Sedláček
13:00 – 13:50
CRISPR
CRISPR, R. Sedláček
J. Doležel
14:10 – 15:00
Organization and function of the 3D genome
Organization and function of the 3D genome, J. Doležel
MODULE:

Biomedicine (pathogens)

Wednesday 10. 11. 2021
O. Štěpánek
09:00 – 09:50
Adaptive immunity
Adaptive immunity, O. Štěpánek
K. Holada
09:50 – 10:40
Prions
Prions, K. Holada
P. Šebo
11:00 – 11:50
Molecular and genetic bases of bacterial virulence
Molecular and genetic bases of bacterial virulence, P. Šebo
L. Macůrek
13:00 – 13:50
DNA damage response and cellular checkpoints in cancer
DNA damage response and cellular checkpoints in cancer, L. Macůrek
R. Spíšek
14:10 – 15:00
Tumor immunology and cancer immunotherapy
Tumor immunology and cancer immunotherapy, R. Spíšek
MODULE:

Career Development

Thursday 11. 11. 2021
P. Svoboda
09:00 – 09:50
Scientific misconduct
Scientific misconduct, P. Svoboda
K. Bohuslavová
10:00 – 11:50
Introduction into English in Academic Writing
Introduction into English in Academic Writing, K. Bohuslavová
D. Staněk, P. Svoboda
13:00 – 14:30
Career paths & interviews
Career paths & interviews, D. Staněk, P. Svoboda
MODULE:

PhD/postdoc discussion panel

Thursday 11. 11. 2021
14:45 – 15:45
Movie – Naturally Obsessed – The Making of a Scientist (document)
Movie – Naturally Obsessed – The Making of a Scientist (document)
discussion panel
16:00 – 17:30
Career in science
Career in science, discussion panel
17:30 – 21:00
Social event
Social event
MODULE:

PhD Talks

Friday 12. 11. 2021
L. Knoblochová
09:30 – 10:00
Chk1 kinase is essential for DNA integrity protection during early embryonic development in mice
Chk1 kinase is essential for DNA integrity protection during early embryonic development in mice, L. Knoblochová
Z. Loubalová
10:00 – 10:30
piRNA pathway in Golden hamsters
piRNA pathway in Golden hamsters, Z. Loubalová
O. Tsyklauri
10:50 – 11:20
Tregs in autoimmunity and cancer
Tregs in autoimmunity and cancer, O. Tsyklauri
S. Grusanovic
11:20 – 11:50
Chronic inflammation instructs hematopoietic stem cells to lose their fitness
Chronic inflammation instructs hematopoietic stem cells to lose their fitness, S. Grusanovic

Programme / Lectures – 2022

MODULE:

DNA/nucleus

Monday 31. 10. 2022
08:30 – 09:30
registration, refreshment
registration, refreshment
J. Jonák/P. Svoboda
09:30 – 09:50
opening remarks
opening remarks, J. Jonák/P. Svoboda
M. Sztacho
09:50 – 10:40
The cell nucleus: relationship between microstructure and function
The cell nucleus: relationship between microstructure and function, M. Sztacho
J. Hejnar
11:00 – 11:50
Antiviral prospects of gene editing technology
Antiviral prospects of gene editing technology, J. Hejnar
J. Doležel
13:00 – 13:50
Organization and function of the 3D genome
Organization and function of the 3D genome, J. Doležel
J. Pačes
14:10 – 15:00
Human genome structure and evolution
Human genome structure and evolution, J. Pačes
MODULE:

RNA Biology

Tuesday 1. 11. 2022
L. Krásný
09:00 – 09:50
RNA polymerase: The pivotal enzyme of gene expression
RNA polymerase: The pivotal enzyme of gene expression, L. Krásný
R. Štefl
09:50 – 10:40
Organization and regulation of RNA polymerase II transcription
Organization and regulation of RNA polymerase II transcription, R. Štefl
H. Macíčková-Cahová
11:00 – 11:50
Non-canonical RNA caps – from their discovery to their role
Non-canonical RNA caps – from their discovery to their role, H. Macíčková-Cahová
R. Pillai
13:00 – 13:50
piRNA pathway
piRNA pathway, R. Pillai
L. Valášek
14:10 – 15:00
The mechanism of eucaryotic translation
The mechanism of eucaryotic translation, L. Valášek
MODULE:

Proteins

Wednesday 2. 11. 2022
D. Staněk
09:00 – 09:50
Regulation of RNA splicing
Regulation of RNA splicing, D. Staněk
K. Holada
09:50 – 10:40
Prions, prion strains and expanding universe of prion diseases
Prions, prion strains and expanding universe of prion diseases, K. Holada
V. Veverka
11:00 – 11:50
Structural Biology Tools
Structural Biology Tools, V. Veverka
J. Petrák
13:00 – 13:50
Proteins, proteomes and proteomics
Proteins, proteomes and proteomics, J. Petrák
G. Demo
14:10 – 15:00
Ribosome structure and function
Ribosome structure and function, G. Demo
MODULE:

Cell Biology

Thursday 3. 11. 2022
J. Pláteník
09:00 – 09:50
Cellular iron as a cause of oxidative stress, DNA damage and ferroptosis
Cellular iron as a cause of oxidative stress, DNA damage and ferroptosis, J. Pláteník
Pa. Dráber
09:50 – 10:40
Microtubules and signal transduction
Microtubules and signal transduction, Pa. Dráber
L. Macůrek
11:00 – 11:50
Genome integrity in healthy cells and cancer
Genome integrity in healthy cells and cancer, L. Macůrek
A. Ziková
13:00 – 13:50
Multifaceted Mitochondrial ATP synthases
Multifaceted Mitochondrial ATP synthases, A. Ziková
M. Jindra
14:10 – 15:00
Insect development and its hormonal regulation
Insect development and its hormonal regulation, M. Jindra
MODULE:

Cell Biology

Friday 4. 11. 2022
V. Hořejší
09:00 – 09:50
Membrane microdomains and their biological roles – facts and artifacts
Membrane microdomains and their biological roles – facts and artifacts, V. Hořejší
K. Rohlenová
09:50 – 10:40
Endothelial cells: Metabolism and heterogeneity in disease
Endothelial cells: Metabolism and heterogeneity in disease, K. Rohlenová
V. Varga
11:00 – 11:50
Flagella & Cilia
Flagella & Cilia, V. Varga
MODULE:

Genomics

Monday 7. 11. 2022
P. Svoboda
09:00 – 09:50
Strategies for manipulating gene expression
Strategies for manipulating gene expression, P. Svoboda
Z. Sedláček
09:50 – 10:40
Genetics of intellectual disability and autism
Genetics of intellectual disability and autism, Z. Sedláček
J. Forejt
11:00 – 11:50
Meiotic recombination & hybrid sterility
Meiotic recombination & hybrid sterility, J. Forejt
M. Kolář
13:00 – 13:50
High throughut gene expression analysis
High throughut gene expression analysis, M. Kolář
T. Stopka
14:10 – 15:00
Leukemogenesis:  genetics vs epigenetics
Leukemogenesis:  genetics vs epigenetics, T. Stopka
MODULE:

Biomedicine

Tuesday 8. 11. 2022
R. Spíšek
09:00 – 09:50
Tumor Immunology and Cancer Immunotherapy
Tumor Immunology and Cancer Immunotherapy, R. Spíšek
O. Štěpánek
09:50 – 10:40
Memory of the immune system
Memory of the immune system, O. Štěpánek
S. Kmoch
11:00 – 11:50
Rare genetic variants in Mendelian complex diseases
Rare genetic variants in Mendelian complex diseases, S. Kmoch
K. Říha
13:00 – 13:50
Comparative biology of aging
Comparative biology of aging, K. Říha
J. Procházka
14:10 – 15:00
Role of enamel matrix proteins in biomineralization and trace of their evolution in gene pleiotropy
Role of enamel matrix proteins in biomineralization and trace of their evolution in gene pleiotropy, J. Procházka
MODULE:

Biomedicine

Wednesday 9. 11. 2022
P. Šebo
09:00 – 09:50
Molecular tricks of bacterial pathogens to manipulate the hostimmunity
Molecular tricks of bacterial pathogens to manipulate the hostimmunity, P. Šebo
H. Hanzlíková
09:50 – 10:40
DNA strand breaks and neurodegenerative disease
DNA strand breaks and neurodegenerative disease, H. Hanzlíková
A. Sumová
11:00 – 11:50
Biological clock
Biological clock, A. Sumová
M. Alberich-Jorda
13:00 – 13:50
Transcriptional regulation during blood formation
Transcriptional regulation during blood formation, M. Alberich-Jorda
Z. Kleibl
14:10 – 15:00
Germline genetic changes causing human tumors
Germline genetic changes causing human tumors, Z. Kleibl
MODULE:

Career Development

Thursday 10. 11. 2022
K. Bohuslavová
09:00 – 10:40
Writing in scientific English
Writing in scientific English, K. Bohuslavová
P. Svoboda
11:00 – 11:50
Scientific misconduct
Scientific misconduct, P. Svoboda
D. Staněk
13:00 – 13:50
Careers
Careers, D. Staněk
P. Svoboda
14:00 – 15:00
Scientific communication
Scientific communication, P. Svoboda
moderated discussion
15:30 – 17:00
Career in Science – experience of junior groupleaders
Career in Science – experience of junior groupleaders, moderated discussion
17:00 – 22:00
Party
Party
MODULE:

Devbiol

Friday 11. 11. 2022
T. Middelkoop
09:00 – 09:50
Converting cellular-scale chirality to organismal left-right symmetry breaking
Converting cellular-scale chirality to organismal left-right symmetry breaking, T. Middelkoop
P. Fabián
09:50 – 10:40
Development of the head and neck
Development of the head and neck, P. Fabián
J. Mašek
11:00 – 11:50
Notch signaling
Notch signaling, J. Mašek

Programme / Lectures – 2023

MODULE:

DNA/nucleus

Monday 30. 10. 2023
J. Jonák/P. Svoboda
08:40 – 09:00
opening remarks & organizational items
opening remarks & organizational items, J. Jonák/P. Svoboda
P. Hozák
09:00 – 09:50
The cell nucleus: relationship between microstructure and function
The cell nucleus: relationship between microstructure and function, P. Hozák
J. Pačes
09:50 – 10:40
Human genome structure and evolution
Human genome structure and evolution, J. Pačes
P. Svoboda
11:00 – 11:50
Evolution of genes and gene expression programs
Evolution of genes and gene expression programs, P. Svoboda
J. Doležel
13:00 – 13:50
Organization and function of the 3D genome
Organization and function of the 3D genome, J. Doležel
J. Fajkus
14:10 – 15:00
Telomeres and telomerases: structure, functions and evolution
Telomeres and telomerases: structure, functions and evolution, J. Fajkus
MODULE:

RNA Biology

Tuesday 31. 10. 2023
D. Staněk
09:00 – 09:50
Alternative splicing
Alternative splicing, D. Staněk
D. Blažek
09:50 – 10:40
Cyclin-dependent kinases in transcription and splicing
Cyclin-dependent kinases in transcription and splicing, D. Blažek
Z. Paris
11:00 – 11:50
tRNA metabolism
tRNA metabolism, Z. Paris
M. O’Connell
13:00 – 13:50
dsRNA response in innate immunity/ADARs
dsRNA response in innate immunity/ADARs, M. O’Connell
P. Svoboda
14:10 – 15:00
Genome defense by small RNAs in mammals
Genome defense by small RNAs in mammals, P. Svoboda
MODULE:

Proteins

Wednesday 1. 11. 2023
L. Valášek
09:00 – 09:50
Eukaryotic protein synthesis
Eukaryotic protein synthesis, L. Valášek
J. Petrák
09:50 – 10:40
Proteomics – expectation, promises and reality
Proteomics – expectation, promises and reality, J. Petrák
P. Řezáčová
11:00 – 11:50
Protein structure determination by X-ray crystallography
Protein structure determination by X-ray crystallography, P. Řezáčová
L. Čermák
13:00 – 13:50
Protein turnover in cancer and development: insights into cellular dynamics
Protein turnover in cancer and development: insights into cellular dynamics, L. Čermák
J. Vondrášek
14:10 – 15:00
Protein structure predictions
Protein structure predictions, J. Vondrášek
MODULE:

Cell Biology, Cytoskeleton & Co.

Thursday 2. 11. 2023
Z. Lánský
09:00 – 09:50
Ensemble dynamics of cytoskeletal proteins
Ensemble dynamics of cytoskeletal proteins, Z. Lánský
Pa. Dráber
09:50 – 10:40
Microtubules and signal transduction
Microtubules and signal transduction, Pa. Dráber
V. Varga
11:00 – 11:50
Biology of eukaryotic flagella and cilia
Biology of eukaryotic flagella and cilia, V. Varga
M Gregor
13:00 – 13:50
Cytoskeletal organization in cell and tissue mechanics
Cytoskeletal organization in cell and tissue mechanics, M Gregor
S. Osmanagic-Myers
14:10 – 15:00
Nuclear mechanobiology and aging
Nuclear mechanobiology and aging, S. Osmanagic-Myers
MODULE:

Cell Biology

Friday 3. 11. 2023
J. Pláteník
09:00 – 09:50
Cellular iron as a source of oxidative stress, DNA damage and ferroptosis
Cellular iron as a source of oxidative stress, DNA damage and ferroptosis, J. Pláteník
V. Hampl
09:50 – 10:40
Mitochondria
Mitochondria, V. Hampl
A. Nadler
11:00 – 11:50
Cell biology of lipids – current challenges & approaches
Cell biology of lipids – current challenges & approaches, A. Nadler
MODULE:

Development

Monday 6. 11. 2023
H. Fulková
09:00 – 09:50
Oocyte-to-embryo transition
Oocyte-to-embryo transition, H. Fulková
L. Láníková
09:50 – 10:40
Therapeutic models in regenerative medicine and oncology
Therapeutic models in regenerative medicine and oncology, L. Láníková
P. Fabian
11:00 – 11:50
Zebrafish as a model system in developmental biology
Zebrafish as a model system in developmental biology, P. Fabian
A. Hejnol
13:00 – 13:50
Comparative developmental biology
Comparative developmental biology, A. Hejnol
O. Svoboda
14:10 – 15:00
Hematopoiesis
Hematopoiesis, O. Svoboda
MODULE:

Biomedicine, Genetics & Genomics

Tuesday 7. 11. 2023
R. Spíšek
09:00 – 09:50
Tumor immunology and cancer immunotherapy
Tumor immunology and cancer immunotherapy, R. Spíšek
M. Kolář
09:50 – 10:40
Reading biological information
Reading biological information, M. Kolář
J. Procházka
11:00 – 11:50
Epigenetic disorders: from understanding to potential therapy
Epigenetic disorders: from understanding to potential therapy, J. Procházka
R. Sedláček
13:00 – 13:50
Guided nucleases – an introduction
Guided nucleases – an introduction, R. Sedláček
R.O. Bak
14:10 – 15:00
CRISPR/Cas in biomedicine
CRISPR/Cas in biomedicine, R.O. Bak
MODULE:

Biomedicine, Cancer

Wednesday 8. 11. 2023
Z. Storchová
09:00 – 09:50
Chromosomal aberrations in cancer cells – the penalties and the rewards
Chromosomal aberrations in cancer cells – the penalties and the rewards, Z. Storchová
H. Hanzlíková
09:50 – 10:40
ADP-ribose metabolism, DNA strand breaks and human disease
ADP-ribose metabolism, DNA strand breaks and human disease, H. Hanzlíková
H. Polášek-Sedláčková
11:00 – 11:50
Regulation of DNA replication in healthy and cancer cells
Regulation of DNA replication in healthy and cancer cells, H. Polášek-Sedláčková
K. Rohlenová
13:00 – 13:50
Metabolic communication in tumors: focus on nucleotide metabolism
Metabolic communication in tumors: focus on nucleotide metabolism, K. Rohlenová
L. Macůrek
14:10 – 15:00
DNA damage response and cellular checkpoints in cancer
DNA damage response and cellular checkpoints in cancer, L. Macůrek
MODULE:

Biomedicine, Immuno

Thursday 9. 11. 2023
T. Stopka
09:00 – 09:50
Epigenetic regulation in leukemia predisposition and myelodysplastic syndromes
Epigenetic regulation in leukemia predisposition and myelodysplastic syndromes, T. Stopka
J. Starková
09:50 – 10:40
Metabolic vulnerabilities in leukemia
Metabolic vulnerabilities in leukemia, J. Starková
K. Škvárová
11:00 – 11:50
Gene editing strategies for correcting inherited bone marrow failure syndromes
Gene editing strategies for correcting inherited bone marrow failure syndromes, K. Škvárová
Pe. Dráber jun.
13:00 – 13:50
Targeting proinflammatory cytokines in autoimmune diseases
Targeting proinflammatory cytokines in autoimmune diseases, Pe. Dráber jun.
S. Kmoch
14:10 – 15:00
Rare genetic variants in Mendelian complex diseases
Rare genetic variants in Mendelian complex diseases, S. Kmoch
MODULE:

Career Development, Discussion Panel

Thursday 9. 11. 2023
D. Staněk
15:20 – 16:30
Career paths – research and alternatives
Career paths – research and alternatives, D. Staněk
16:30 – 18:00
Career reflections and decisions: open discussion with people with different career paths
Career reflections and decisions: open discussion with people with different career paths
18:00 – 22:00
dinner & socializing
dinner & socializing
MODULE:

Career Development

Friday 10. 11. 2023
P. Svoboda
09:00 – 10:10
Decision points: postdoc selection and postdoc interview
Decision points: postdoc selection and postdoc interview, P. Svoboda
P. Svoboda
10:40 – 12:00
Scientific misconduct
Scientific misconduct, P. Svoboda
12:00
Credits
Credits

Programme / Lectures – 2020

The course programme will be published in the coming days.

MODULE:

DNA/nucleus

Monday 2. 11. 2020
J. Jonák/P. Svoboda
09:30 – 09:50
opening remarks
opening remarks, J. Jonák/P. Svoboda
P. Hozák
09:50 – 10:40
The cell nucleus: relationship between microstructure and function
The cell nucleus: relationship between microstructure and function, P. Hozák
J. Hejnar
11:00 – 11:50
Antiviral prospects of gene editing technology
Antiviral prospects of gene editing technology, J. Hejnar
J. Fajkus
13:00 – 13:50
The story of onion: how its unusual telomeres allowed us to identify authentic RNA subunits of plant telomerases
The story of onion: how its unusual telomeres allowed us to identify authentic RNA subunits of plant telomerases, J. Fajkus
J. Pačes
14:10 – 15:00
Human genome structure and evolution
Human genome structure and evolution, J. Pačes
MODULE:

RNA Biology

Tuesday 3. 11. 2020
L. Krásný
09:00 – 09:50
RNA polymerase: The pivotal enzyme of gene expressionRNA polymerase: Function and cell to cell communication
RNA polymerase: The pivotal enzyme of gene expressionRNA polymerase: Function and cell to cell communication, L. Krásný
R. Stefl
09:50 – 10:40
Eukaryotic transcription by RNA polymerase II
Eukaryotic transcription by RNA polymerase II, R. Stefl
H. Macíčková Cahová
11:00 – 11:50
Covalent RNA modifications
Covalent RNA modifications, H. Macíčková Cahová
P. Svoboda
13:00 – 13:50
Mammalian small RNA pathways
Mammalian small RNA pathways, P. Svoboda
D. Staněk
14:10 – 15:00
Regulation of RNA splicing
Regulation of RNA splicing, D. Staněk
MODULE:

Proteins

Wednesday 4. 11. 2020
L. Valášek
09:00 – 09:50
The mechanism of eucaryotic translation
The mechanism of eucaryotic translation, L. Valášek
K. Holada
09:50 – 10:40
Prions, prion strains and expanding universe of prion diseases
Prions, prion strains and expanding universe of prion diseases, K. Holada
P. Řezáčová
11:00 – 11:50
Protein structure determination by X-ray crystallography
Protein structure determination by X-ray crystallography, P. Řezáčová
J. Petrák
13:00 – 13:50
Proteins, Proteomes and Proteomics
Proteins, Proteomes and Proteomics, J. Petrák
K. Stříšovský
14:10 – 15:00
Membrane protein biogenesis and quality control
Membrane protein biogenesis and quality control, K. Stříšovský
MODULE:

Cell Biology

Thursday 5. 11. 2020
J. Pláteník
09:00 – 09:50
Cellular iron as a cause of oxidative stress, DNA damage and ferroptosis
Cellular iron as a cause of oxidative stress, DNA damage and ferroptosis, J. Pláteník
Pa. Dráber
09:50 – 10:40
Microtubules and signal transduction
Microtubules and signal transduction, Pa. Dráber
A. Zikova
11:00 – 11:50
Multifaceted Mitochondrial ATP synthases
Multifaceted Mitochondrial ATP synthases, A. Zikova
M. Jindra
13:00 – 13:50
Molecular genetics and chemical biology join forces to tease apart insect hormonal signaling
Molecular genetics and chemical biology join forces to tease apart insect hormonal signaling, M. Jindra
L. Macůrek
14:10 – 15:00
Genome integrity in healthy cells and cancer
Genome integrity in healthy cells and cancer, L. Macůrek
MODULE:

Cell Biology

Friday 6. 11. 2020
V. Hořejší
09:00 – 09:50
Membrane microdomains and their biological roles – facts and artifacts
Membrane microdomains and their biological roles – facts and artifacts, V. Hořejší
V. Varga
09:50 – 10:40
Flagella & Cilia
Flagella & Cilia, V. Varga
M. Alberich Jordà
11:00 – 11:50
Transcriptional regulation during blood formation
Transcriptional regulation during blood formation, M. Alberich Jordà
MODULE:

Genomics

Monday 9. 11. 2020
S. Kmoch
09:00 – 09:50
Rare genetic variants in Mendelian complex diseases
Rare genetic variants in Mendelian complex diseases, S. Kmoch
Z. Sedláček
09:50 – 10:40
Genetics of autism and intellectual disability
Genetics of autism and intellectual disability, Z. Sedláček
J. Forejt
11:00 – 11:50
Meiotic recombination & hybrid sterility
Meiotic recombination & hybrid sterility, J. Forejt
J. Doležel
13:00 – 13:50
Organization and function of the 3D genome
Organization and function of the 3D genome, J. Doležel
P. Kašpárek
14:10 – 15:00
Mouse genome engineering by CRISPR technology
Mouse genome engineering by CRISPR technology, P. Kašpárek
MODULE:

Biomedicine

Tuesday 10. 11. 2020
R. Špíšek
09:00 – 09:50
Tumor immunology and cancer immunotherapy
Tumor immunology and cancer immunotherapy, R. Špíšek
J. Neužil
09:50 – 10:40
Mitochondria as a therapeutic target: focus on cancer
Mitochondria as a therapeutic target: focus on cancer, J. Neužil
T. Stopka
11:00 – 11:50
Leukemogenesis: genetics vs epigenetics
Leukemogenesis: genetics vs epigenetics, T. Stopka
K. Říha
13:00 – 13:50
Comparative biology of aging
Comparative biology of aging, K. Říha
J. Procházka
14:10 – 15:00
Function of ameloblastin in enamel formation and beyond
Function of ameloblastin in enamel formation and beyond, J. Procházka
MODULE:

Biomedicine (pathogens)

Wednesday 11. 11. 2020
O. Štěpánek
09:00 – 09:50
Memory of the immune system
Memory of the immune system, O. Štěpánek
P. Šebo
09:50 – 10:40
Molecular tricks of bacterial pathogens to manipulate the host
Molecular tricks of bacterial pathogens to manipulate the host, P. Šebo
P. Plevka
11:00 – 11:50
Genome release mechanism of picorna-like-viruses
Genome release mechanism of picorna-like-viruses, P. Plevka
J. Konvalinka
13:00 – 13:50
Viral proteases as drug targets: from HIV to hepatitis C virus and coronavirus
Viral proteases as drug targets: from HIV to hepatitis C virus and coronavirus, J. Konvalinka
R. Nencka
14:10 – 15:00
Emerging viruses – medicinal chemistry guided by structural biology
Emerging viruses – medicinal chemistry guided by structural biology, R. Nencka
MODULE:

Career Day

Thursday 12. 11. 2020
P. Svoboda
09:00 – 09:50
Scientific misconduct
Scientific misconduct, P. Svoboda
K. Bohuslavová
10:00 – 11:50
Writing in scientific English
Writing in scientific English, K. Bohuslavová
D. Staněk
13:00 – 13:50
Careers
Careers, D. Staněk
P. Svoboda
14:00 – 15:00
Scientific communication
Scientific communication, P. Svoboda
MODULE:

PhD Talks

Friday 13. 11. 2020
S. Grusanovic
09:30 – 10:00
Chronic inflammation instructs hematopoietic stem cells to lose their fitness
Chronic inflammation instructs hematopoietic stem cells to lose their fitness, S. Grusanovic
S. Kataruka
10:00 – 10:30
miRNA pathway in mouse oocytes
miRNA pathway in mouse oocytes, S. Kataruka
O. Tsyklauri
10:50 – 11:20
Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome
Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome, O. Tsyklauri
M. Kovář
11:20 – 11:50
Haematopoiesis in sea lamprey
Haematopoiesis in sea lamprey, M. Kovář

Programme / Lectures – 2019

The course programme will be published in the coming days.

MODULE:

DNA/nucleus

Monday 4. 11. 2019
08:30 – 09:30
registration, refreshment
registration, refreshment
J. Jonák/P. Svoboda
09:30 – 09:50
opening remarks
opening remarks, J. Jonák/P. Svoboda
P. Hozák
09:50 – 10:40
The nucleus: an old organelle with new structures
PDF
The nucleus: an old organelle with new structures, P. Hozák
J. Pačes
11:00 – 11:50
Human genome structure and evolution
PDF
Human genome structure and evolution, J. Pačes
A. Stark
13:00 – 13:50
Systems biology of regulatory motifs
Systems biology of regulatory motifs, A. Stark
P. Kašpárek
14:10 – 15:00
Targeted genomic modifications (Mouse genome engineering by CRISPR technology)
PDF
Targeted genomic modifications (Mouse genome engineering by CRISPR technology), P. Kašpárek
MODULE:

RNA Biology

Tuesday 5. 11. 2019
L. Krásný
09:00 – 09:50
RNA Polymerase: Ready Steady Go!
PDF
RNA Polymerase: Ready Steady Go!, L. Krásný
S. Vaňáčová
09:50 – 10:40
The tale of (more than) two tails: RNA surveillance in eukaryotic cells
PDF
The tale of (more than) two tails: RNA surveillance in eukaryotic cells, S. Vaňáčová
D. Staněk
11:00 – 11:50
Regulation of alternative splicing
PDF
Regulation of alternative splicing, D. Staněk
M. O’Connell
13:00 – 13:50
RNA Editing/Modification
PDF
RNA Editing/Modification, M. O’Connell
J. Brennecke
14:10 – 15:00
Genetic innovation in genome-transposon conflicts
Genetic innovation in genome-transposon conflicts, J. Brennecke
MODULE:

Proteins

Wednesday 6. 11. 2019
L. Valášek
09:00 – 09:50
Mystery of the Beginning and the End – The Mechanism of Eukaryotic Translation
PDF
Mystery of the Beginning and the End – The Mechanism of Eukaryotic Translation, L. Valášek
L. Čermák
09:50 – 10:40
Protein stability
PDF
Protein stability, L. Čermák
P. Řezáčová
11:00 – 11:50
Protein structure determination by X-ray crystallography
PDF
Protein structure determination by X-ray crystallography, P. Řezáčová
J. Petrák
13:00 – 13:50
Proteins, Proteomes and Proteomics
PDF
Proteins, Proteomes and Proteomics, J. Petrák
K. Holada
14:10 – 15:00
Prions, prion strains and expanding universe of prion diseases
PDF
Prions, prion strains and expanding universe of prion diseases, K. Holada
MODULE:

Cell Biology

Thursday 7. 11. 2019
J. Pláteník
09:00 – 09:50
Cellular iron as a source of oxygen radicals and DNA damage
PDF
Cellular iron as a source of oxygen radicals and DNA damage, J. Pláteník
V. Varga
09:50 – 10:40
Biology of eukaryotic flagella and cilia
PDF
Biology of eukaryotic flagella and cilia, V. Varga
Pa. Dráber
11:00 – 11:50
Microtubules and signal transduction
PDF
Microtubules and signal transduction, Pa. Dráber
P. Doležal
13:00 – 13:50
Cellular organelles specific to eukaryotic pathogens
PDF
Cellular organelles specific to eukaryotic pathogens, P. Doležal
H. Hanzlíková
14:10 – 15:00
DNA repair
PDF
DNA repair, H. Hanzlíková
MODULE:

Signaling

Friday 8. 11. 2019
K. Stříšovský
09:00 – 09:50
Intramembrane proteolytic systems in cellular signaling, homeostasis and quality control
Intramembrane proteolytic systems in cellular signaling, homeostasis and quality control, K. Stříšovský
P. Bartůněk
09:50 – 10:40
Small molecules as tools for dissectingh signalling pathways
Small molecules as tools for dissectingh signalling pathways, P. Bartůněk
V. Hořejší
11:00 – 11:50
Membrane heterogenity: Dynamic nanodomains, lipid shels a realistic model?
PDF
Membrane heterogenity: Dynamic nanodomains, lipid shels a realistic model?, V. Hořejší
MODULE:

Development

Monday 11. 11. 2019
P. Tomančák
09:00 – 09:50
Drosophila as a model system to study developmental processes
Drosophila as a model system to study developmental processes, P. Tomančák
H. Fulková
09:50 – 10:40
The maternal nucleolus and embryonic ribosome biogenesis
PDF
The maternal nucleolus and embryonic ribosome biogenesis, H. Fulková
P. Svoboda
11:00 – 11:50
Evolution of genes and gene expression programs – Stories of emerging functions
PDF
Evolution of genes and gene expression programs – Stories of emerging functions, P. Svoboda
J. Doležel
13:00 – 13:50
Analysis of complex plant genomes
PDF
Analysis of complex plant genomes, J. Doležel
MODULE:

Genomics

Tuesday 12. 11. 2019
J. Hejnar
09:00 – 09:50
Retroviruses Advances in Molecular Genetics
PDF
Retroviruses Advances in Molecular Genetics, J. Hejnar
G. Michlits
09:50 – 10:40
CRISPR-based mutation screen
PDF
CRISPR-based mutation screen, G. Michlits
Z. Sedláček
11:00 – 11:50
Genetics of autism and intellectual disability
PDF
Genetics of autism and intellectual disability, Z. Sedláček
S. Kmoch
13:00 – 13:50
Rare genetic variants in Mendelian and complex diseases
PDF
Rare genetic variants in Mendelian and complex diseases, S. Kmoch
J. Forejt
14:10 – 15:00
From hybrid sterility to PRDM9 histone methyltransferase and back
PDF
From hybrid sterility to PRDM9 histone methyltransferase and back, J. Forejt
MODULE:

Biomedicine

Wednesday 13. 11. 2019
T. Stopka
09:00 – 09:50
Leukemogenesis: genetics vs. epigenetics
PDF
Leukemogenesis: genetics vs. epigenetics, T. Stopka
R. Špíšek
09:50 – 10:40
Tumor immunology and cancer immunotherapy
PDF
Tumor immunology and cancer immunotherapy, R. Špíšek
O. Štěpánek
11:00 – 11:50
T-cell Total Recall: Reals and Fakes of the T-cell memory
PDF
T-cell Total Recall: Reals and Fakes of the T-cell memory, O. Štěpánek
L. Macůrek
13:00 – 13:50
DNA damage response and cell cycle checkpoints
PDF
DNA damage response and cell cycle checkpoints, L. Macůrek
P. Šebo
14:10 – 15:00
Molecular tricks of host-pathogen interactions
PDF
Molecular tricks of host-pathogen interactions, P. Šebo
MODULE:

Career Day

Thursday 14. 11. 2019
K. Bohuslavová
09:00 – 10:40
Introduction into English in Academic Writing
Introduction into English in Academic Writing, K. Bohuslavová
P. Svoboda
11:00 – 11:50
(Research) Ethics
PDF
(Research) Ethics, P. Svoboda
D. Staněk
13:00 – 13:50
Career in Life-Sciences
PDF
Career in Life-Sciences, D. Staněk
Invited speakers
14:10 – 15:40
Career paths in science
Career paths in science, Invited speakers
Research and alternatives – J. Moos (i&i Prague)
PDF
Research and alternatives – J. Moos (i&i Prague)
There is life after academia – M. Dienstbier (Diana Biotech)
PDF
There is life after academia – M. Dienstbier (Diana Biotech)
P. Svoboda
16:00 – 17:00
Postdoc interviews
PDF
Postdoc interviews, P. Svoboda
MODULE:

PhD Talks

Friday 15. 11. 2019
V. Horková
09:30 – 10:00
Coreceptor-bound Lck: 30-year-old mystery coming to its end
PDF
Coreceptor-bound Lck: 30-year-old mystery coming to its end, V. Horková
V. Dostál
10:00 – 10:30
WASH complex and the retromer: the story of two endosomal complexes
PDF
WASH complex and the retromer: the story of two endosomal complexes, V. Dostál
K. Klimešová
10:50 – 11:20
SART3 and spliceosomal assembly
PDF
SART3 and spliceosomal assembly, K. Klimešová
V. Henrichs
11:20 – 11:50
Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
PDF
Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments, V. Henrichs